Neath have a tricky match at Pontypridd to contend with, though the home side will be without their former Wales cap Dale McIntosh, who broke a leg at Aberavon last week.
Cardiff go to Bedwas for the first time in a league match, though they have played there in cup rugby and in the Bedwas Centenary season. Caerphilly will make the trip to Bridgend hoping to improve considerably on their worst showing of the season at Cardiff last week, while Cross Keys face a raw young
Llanelli side and Newbridge will face an in-form Swansea if the hosts can field a fit front row.
In the other two matches, both in Gwent, Ebbw Vale are at home to Llandovery and Pontypool entertain Carmarthen Quins, though the odds appear to be on away victories.