Caerphilly will be looking to stop their slide when they entertain Swansea and Cardiff hope to fly Nick Macleod and Andrew Lewis back from Scotland in time to meet Cross Keys.
Llanelli will give their young squad another runout at home to Bedwas and Aberavon meet a Pontypool side that are slipping fast down the table, while the best contest on a dry day could be at Llandovery, where third-placed Pontypridd are the visitors.
One match will kick off on Friday evening (7.00pm) when Bridgend hope to follow up their cup success with a league win over Newbridge.
