Unbeaten Loughor will take the chance to join Gorseinon on 21 points at the top of the West table if they can win at Hendy, while Goreinon themselves have the chance of moving to 24 points if they can win at Tumble.
In the South-West, Cwmgors will go into second spot if they can win at Nantyffyllon, while Brynamman and Seven Sisters have a personal duel with both having won just twice thus far.