Hamilton, who will be winning his 24th cap, replaces Nathan Hines who has not recovered sufficiently from injury he sustained in Sunday’s Murrayfield meeting with France.
Scotland team doctor James Robson said: “Nathan suffered a calf strain and aggravated an old ankle injury during the match at the weekend.
“Whilst the injury has settled considerably it is not at a level adequate for exposure to the rigours of test match rugby and therefore Nathan is withdrawn from selection.”
Scotland coach Andy Robinson wished Hines a speedy recovery. He added: “I welcome Jim back into the squad following his own recovery from injury.
“We’re going with Jim as he’s like for like with Nathan and will help us to get a platform should we look to get our mauling game going. Jim is also an experienced player.”
