Andy Robinson, who today also signed a contract extension to remain at the helm of Scottish rugby until the end of 2015, has made just a solitary change to the match-day 22, hooker Scott Lawson called onto the replacements bench in place of the injured Dougie Hall.
Wings Max Evans (dead leg) and Nikki Walker a (knee) and scrum-half Rory Lawson (back) have all recovered from knocks they picked up in the defeat to France on the opening weekend to take their places in the starting XV.
Wales will look for a repeat of their last performance in the Scottish capital when they beat their hosts 26 v 13 on their way to lifting the 2008 Grand Slam title.
Scotland: H Southwell (Stade Francais); N Walker (Ospreys), J Ansbro (Northampton Saints), N De Luca (Edinburgh), M Evans (Glasgow Warriors); D Parks (Cardiff Blues), R Lawson (Gloucester); A Jacobsen (Edinburgh), R Ford (Edinburgh), E Murray (Northampton Saints), R Gray (Glasgow Warriors), A Kellock (Glasgow Warriors, capt), N Hines (Leinster), J Barclay (Glasgow Warriors), K Brown (Saracens)
Replacements: S Lawson (Gloucester), M Low (Glasgow Warriors), R Vernon (Glasgow Warriors), R Rennie (Edinburgh), M Blair (Edinburgh), R Jackson (Glasgow Warriors), S Lamont (Scarlets)
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