The Wizards have won 13 of their 19 league games this season but lost in their last league outing at Cross Keys. The Quins have won seven from 22 and have won their last two games with victories over Glamorgan Wanderers and Bedwas.
The match will be the sixteenth time that both sides have met in the league with the Wizards leading the series by 10 wins to four with one game drawn.
The sides met earlier this month at the Talbot Athletic Ground with the Wizards holding on to win 46-40 in a high scoring match that almost saw the West Wales side make an amazing come back after losing 40-19 in the last quarter.
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