Top scorer Jamie Davies returns from holiday at fly half and new skipper Sam Williams returns from Ospreys duty to play at lock and lead the Wizards for the first time.
Also back from the Ospreys is the powerful Morgan Allen in the back row and former Wales Under 20 centre Ben John makes a long-awaited return from injury.
With vice-captain David Pritchard and Dan Davies at scrum half and the former Cardiff and Scarlets player Craig Evans at fly half, the squad looks strong and No 8 Richard Morris will make his 510th club appearance.