They face an inform Cardiff who have won their last four fixtures. After a slow start to the season, the Black and Blues are now up to sixth in the table and will be full of confidence as they go on their travels.
Keys make a total of eight changes to the team that started the defeat at Llanelli last Saturday, three in the backs and five up front.
Luke Ford, Garry Horrigan and Adam Powell start against their former side whilst Leon Andrews and Rhys Dyer will surely appear from the bench.
Gerywn Price again starts in the backrow with Garry Horrigan at hooker.
Cross Keys: 15 Gareth David 14 Elliot Jones 13 Luke Ford 12 Aled James 11 Nathan Trowbridge 10 Dean Gunter 9 Ryan James (c), 1 Anthony Lott 2 Garry Horrigan 3 Craig Gould 4 Danny Hodge 5 Ollie Hodge 6 Jamie Sollis 7 Gerwyn Price 8 Adam Powell.
Replacements: Sean Higgins, Marc Jones, James Johnstone, Rhys Peebles, Scott Matthews, Rhys Dyer, Dorian Jones, Leon Andrews.
Cardiff: TBC