Both teams will be looking to move closer to the top of the table and bridge the gap to fourth place, one currently occupied by Cross Keys.
The two sides boast identical records so far this season, winning four and losing three of their seven league fixtures and are separated only by points difference.
The Blue and Blacks have made six changes as they shuffle their pack following their British & Irish Cup fixtures. Martyn Fowler’s side will be looking for a response after defeats to Bristol and Bridgend halted what the momentum built up run of four successive league wins.
Cardiff Blues full-back Dan Fish is again a welcome addition to the side and is joined in the back three by Richard Smith and captain Shaun Powell. Another man pushing for regular regional honours is Macauley Cook who again starts at lock as he looks to maintain his impressive recent form.
Smith returns from Wales Sevens duty to start on the wing while fellow international Alex Walker has to settle for a place on the bench.
For Llanelli, Dale Ford makes a welcome return after a lengthy lay-off while Adam Powell captains the side from the second row. After returning to winning ways with a British & Irish Cup win over Gala last week, Llanelli will travel to the capital in positive mood.
With just under a third of the league’s fixtures played so far, the encounter is an extremely important one to both sides.
And having won away on a couple of occasions already this season, Llanelli will be hoping for a similar outcome on Saturday.
Cardiff: 15 Dan Fish 14 Richard Smith 13 Owen Williams 12 Max Woodward 11 Shaun Powell (c) 10 Gareth Davies 9 Robert Lewis, 1 Lewis Smout 2 Ethan Lewis 3 Ryan Harford 4 Alwyn Lee 5 Macauley Cook 6 Benjamin Roach 7 Thomas Young 8 Luke Hamilton.
Replacements: Simon Gardiner, Joshua Dunleavy, Callum Jay Lewis, Daniel James Partridge, Reuben Tucker, Alex Walker, William Thomas, Steven Cullen.
Llanelli: 15 Johnny Lewis 14 Dale Ford 13 Chris Keenan 12 Steffan Hughes 11 Kristian Phillips 10 Owen Williams 9 Justin James, 1 Rhys Thomas 2 Craig Hawkins 3 Aled Hopkins 4 Adam Powell (c) 5 Jake Ball 6 Craig Price 7 Duane Eager 8 Ed Price.
Replacements: Jamie Kaijaks, Greg George, Tom Sloane, Nathan White, Stuart Leach, Ryan Jones, Diggy Bird, Kyle Evans.