The north Walians will face either Carmarthen Quins or Bedwas on the weekend of 27th February.
The winners from tonight’s rearranged clash between Bridgend and Cross Keys will face the victor of Neath and Cardiff Met in the quarter-finals.
Pontypridd will tackle Bridgend Athletic on Tuesday to decide who will face the winner between Llanelli and Championship outfit, Merthyr.
The remaining quarter-final will see either Newcastle Emlyn or Ebbw Vale take on Llandovery or Newbridge.
QUARTER FINAL ROUND
To be played the weekend of 27th February 2016
RGC 1404 v Carmarthen Quins / Bedwas
Pontypridd / Bridgend Athletic v Llanelli / Merthyr
Newcastle Emlyn / Ebbw Vale v Llandovery / Newbridge
Bridgend / Cross Keys v Neath / Cardiff Met