The East Wales region travel to Kingsholm on the back of seven straight defeats to take on reigning champions Gloucester, who are on a record run of 15-matches unbeaten in the competition.
The Dragons saved some of their best performances for their run to the semi-finals last year. They beat their regional rivals Cardiff Blues 25-21 in the last-eight, before suffering defeat at Edinburgh in the semi-finals.
And Amos wants his men to rise to the occasion in-front of the Shed at 12:45 on Saturday.
He said: “We are under no illusions. They are a strong side, especially in Europe. It will be a very tough place to go but, in saying that, we have pulled out some big performances against big teams, especially away from home.
“We have beaten Pau, Stade Francais and Newcastle and they have been some of our best performances. Hopefully, we can replicate that.”
Amos has hit some red-hot try-scoring form ahead of Europe’s return. The Wales wing has scored six tries in four games, and is out to continue his domestic run on the European stage. And he is relishing playing in-front of the famous Shed.
He said: “I guess it is one of the stadiums which is the same as ours at Rodney Parade. Teams talk about coming here and having the crowds in the stands on their backs and I suppose it is similar to the Shed.
“I am lucky I don’t really notice the crowd. It is why you play the game, when the crowd is on form, it is much more enjoyable and hopefully we can get a few Dragons fans there as well.”
“We have a chance if we play an expansive game and we have shown in the last two weeks that we can create things when we give it a bit of width. Hopefully we can go to Gloucester and not go into our shells and play with a bit of width.”