Amos, suffered a shoulder injury in the defeat to Australia and has been released back to the Newport Gwent Dragons.
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Giles, who has been an additional player, training alongside the squad since the start of the campaign, is now part of the full squad.
Wales Squad Update: Giles wings in
Related players
Wales have called Ospreys wing Keelan Giles into their 2016 Under Armour Series squad after releasing Hallam Amos due to injury.