Gareth Davies and Gareth Anscombe are named at half-back with Hadleigh Parkes and Jonathan Davies partnering again in the midfield. Josh Adams, George North and Liam Williams make up the back-three.
“We are really happy with the experience we have got in the side,” said Wales head coach Warren Gatland. “We have been on the road for the first two weeks, we are looking forward to being back at home and to build on those first two wins and to build on our performance.
“We’ve had a great two-week lead up to this game, we’ve looked really sharp and the squad are incredibly motivated to kick on.
“We know how important this game is for the rest of the championship. It’s a massive challenge playing against an England team that is playing really well and with a lot of confidence and we’ve got to make it difficult for them on Saturday.
“We are looking forward to it and we know the Welsh fans are too and it’s going to be a huge weekend in the Six Nations.”
Elliot Dee, Nicky Smith and Dillon Lewis provide Wales’ front-row replacements with Adam Beard and Aaron Wainwright completing the forward contingent. Aled Davies, Dan Biggar and Owen Watkin provide the backline cover.
WALES TEAM TO PLAY ENGLAND
(Saturday February 23 KO 16.45 – BBC ONE & S4C)
15. Liam Williams (53 Caps)
14. George North (80 Caps)
13. Jonathan Davies (70 Caps)
12. Hadleigh Parkes (12 Caps)
11. Josh Adams (8 Caps)
10. Gareth Anscombe (23 Caps)
9. Gareth Davies (38 Caps)
1. Rob Evans (32 Caps)
2. Ken Owens (61 Caps)
3. Tomas Francis (37 Caps)
4. Cory Hill (23 Caps)
5. Alun Wyn Jones (122 Caps) (CAPT)
6. Josh Navidi (13 Caps)
7. Justin Tipuric (61 Caps)
8. Ross Moriarty (28 Caps)
REPLACEMENTS:
16. Elliot Dee (15 Caps)
17. Nicky Smith (25 Caps)
18. Dillon Lewis (9 Caps)
19. Adam Beard (10 Caps)
20. Aaron Wainwright (5 Caps)
21. Aled Davies (13 Caps)
22. Dan Biggar (67 Caps)
23. Owen Watkin (10 Caps)