Allen Clarke’s side will welcome the former European champions to the Liberty Stadium on Saturday, November 16 at 17.30pm.
This season’s European campaigns get underway later than usual for 2019-20 because of the Rugby World Cup in Japan.
The Ospreys have been drawn in the toughest pool in the competition alongside defending champions Saracens, French giants Racing 92, and Irish province Munster.
Following their opener against Munster the men from the Liberty Stadium will face Saracens at Allianz Park on Saturday November 23 at 1pm with the game to be shown live on free-to-air broadcaster Channel 4.
They then face a home and away double header with Racing 92 in December before finishing up their pool stage fixtures with a home fixture against Saracens and a trip to Limerick to face Munster.
In the European Challenge Cup, the Scarlets start off with a home fixture against Gallagher Premiership new boys London Irish on Saturday, November 16. The game has an 8pm kick-off.
They travel to Toulon on Friday November 22 with a further 8pm start British time ahead of December fixtures away and at home to another French club in Bayonne.
Cardiff Blues are off to Italy first up for a meeting with Calvisano on the afternoon of Saturday, November 16 with Leicester and Pau heading to the Arms Park in rounds two and three.
Finally, the Dragons kick off by welcoming Castres to Rodney Parade on Saturday November 16 before making the long trip to Krasnodar for another meeting with Russian side Enisei, before return fixtures with Worcester.
For your region’s full fixtures for the 2019-20 campaign, click the links below: