Carre and Lane, who played in the same Wales U18 and U20 sides together, will feature for Wales for the first time in a side captained by Josh Navidi.
Carre will pack down in the front row alongside Scarlets pair Ryan Elias and Samson Lee. Ospreys duo Adam Beard and Bradley Davies form the second row partnership.
Aaron Shingler and James Davies are named in the back row alongside captain Navidi.
Jarrod Evans makes his first start for Wales and links up with Aled Davies at half-back. Owen Watkin and Scott Williams line up in the centre with Lane, Steff Evans and Hallam Amos making up the back-three.
“It is a great opportunity for Rhys and Owen, they have worked hard all summer to get to this point so it will be good for them to get their first international caps and put their hands up for RWC selection after the match,” said Wales head coach Warren Gatland.
“For Josh, it’s a huge honour to be named captain, he has been hugely consistent for us, he has really impressed in the last couple of seasons and he will lead from the front of Saturday and it is a great compliment for him to be awarded the captaincy.
“Saturday is a really big game for the players and I’m really excited about the challenge for this Welsh team. There is so much at stake in terms of RWC selection with a number of positions still up for grabs it will be a huge game.”
Elliot Dee, Rob Evans and Leon Brown provide the front row cover with Jake Ball and Ross Moriarty completing the forward contingent. Tomos Williams, Rhys Patchell and Jonah Holmes are named as the backline cover.
WALES TEAM TO FACE IRELAND, SATURDAY AUGUST 31 (KO 14.30, CHANNEL 4)
15. Hallam Amos (Cardiff Blues)
14. Owen Lane (Cardiff Blues)*
13. Scott Williams (Ospreys)
12. Owen Watkin (Ospreys)
11. Steff Evans (Scarlets)
10. Jarrod Evans (Cardiff Blues)
9. Aled Davies (Ospreys)
1. Rhys Carre (Saracens)*
2. Ryan Elias (Scarlets)
3. Samson Lee (Scarlets)
4. Adam Beard (Ospreys)
5. Bradley Davies (Ospreys)
6. Aaron Shingler (Scarlets)
7. James Davies (Scarlets)
8. Josh Navidi (Cardiff Blues) (CAPT)
Replacements:
16. Elliot Dee (Dragons)
17. Rob Evans (Scarlets)
18. Leon Brown (Dragons)
19. Jake Ball (Scarlets)
20. Ross Moriarty (Dragons)
21. Tomos Williams (Cardiff Blues)
22. Rhys Patchell (Scarlets)
23. Jonah Holmes (Leicester Tigers)
*Uncapped
