Davies, 47, will leave his current role as scrum and assistant forwards coach at Worcester Warriors to join the back-room staff at Rodney Parade.
Dean Ryan, Dragons director of rugby, said: “Investing in our coaching environment will improve us as a team so it’s pleasing to announce Mefin will be joining us next season.
“I know Mefin very well after we worked together during our time at Worcester where he guided the development of Warriors’ talented forwards.
“He has made a real impression in the English Premiership and we now looking forward to seeing the impact he can make at Dragons.”
Former Wales hooker Davies represented Pontypridd, Celtic Warriors, Gloucester, Leicester Tigers and Ospreys during a glittering playing career.
He made his Test for Wales debut in against South Africa in Cape Town in 2002 and featured in the 2003 Rugby World Cup. He was part of the 2005 Six Nations Championship and Grand Slam-winning squad.
Following his retirement, Davies worked as development coach at Ospreys and head coach at Swansea before joining Worcester during Ryan’s tenure at Sixways in 2014.