With former Ospreys openside Sam Underhill ruled out with through injury Mark Wilson is handed the number seven jersey with Anthony Watson the other change on the wing. In an unchanged tight five, Joe Marler, Jamie George and Kyle Sinckler are named in the front row with George Kruis and Maro Itoje in partnership in the second row.
Courtney Lawes and Tom Curry join Wilson in the back-row. Ben Youngs starts at scrum half with George Ford at fly half. Captain Owen Farrell will play inside centre with Manu Tuilagi named at outside centre.
Watson is joined in the back-three by Jonny May and Elliott Daly who starts at full-back. Hooker Luke Cowan-Dickie as well as props Ellis Genge and Will Stuart are named as finishers alongside Joe Launchbury, Charlie Ewels, Ben Earl, Willi Heinz and Henry Slade.
“We’ve had a really good two week preparation – a fallow week in Oxford where we had good training days last Thursday and Friday and three good training days this week culminating in a very good session Wednesday,” said Jones.
“Wales are a very tough, well-coached side and they’ve been building on their attack since Wayne Pivac has taken over. It’s always a tough game against Wales and we know they will bring that toughness to all the contest areas.
“We’re looking forward to playing at home again and getting back out in front of our fantastic fans.”
England: E Daly; A Watson, M Tuilagi, O Farrell, J May; G Ford, B Youngs; J Marler, J George, K Sinckler, M Itoje, G Kruis, C Lawes, M Wilson, T Curry.
Replacements: L Cowan-Dickie, E Genge, W Stuart, J Launchbury, C Ewels, B Earl, W Heinz, H Slade.