North, 28, made his international bow in November 2010 and has amassed 42 tries in his 99 appearances.
North will line-up in the centre alongside Jonathan Davies on Saturday, outside of half-back pairing of Kieran Hardy and Dan Biggar. Josh Adams, Louis Rees-Zammit and Liam Williams comprise the back-three.
Wales name an unchanged front-five with Wyn Jones, Ken Owens and Tomas Francis packing down in the front-row and Adam Beard partnering captain Alun Wyn Jones in the second-row.
Josh Navidi returns to the side to line-up alongside Justin Tipuric and Taulupe Faletau.
“We’ve had a great two weeks leading into this game and we are looking forward to Saturday,” said Wales head coach Wayne Pivac.
“We continue to build and we know there is plenty left in us in terms of improvements from the opening two rounds. We are 2/2 but we want to continue to improve performance wise.
“Saturday is a great milestone for George, it is a huge achievement at his age and we are looking forward to seeing him in action.”
Elliot Dee, Rhodri Jones and Leon Brown provide the front-row cover for Wales with Cory Hill and James Botham completing the forward contingent. Gareth Davies, Callum Sheedy and Uilisi Halaholo provide the back-line cover.
WALES TEAM TO PLAY ENGLAND (SATURDAY FEBRUARY 24, KO 16.45)
1. Wyn Jones (32 Caps)
2. Ken Owens (79 Caps)
3. Tomas Francis (54 Caps)
4. Adam Beard (23 Caps)
5. Alun Wyn Jones (CAPT) (145 Caps)
6. Josh Navidi (25 Caps)
7. Justin Tipuric (82 Caps)
8. Taulupe Faletau (83 Caps);
9. Kieran Hardy (3 Caps)
10. Dan Biggar (89 Caps)
11. Josh Adams (29 Caps)
12. Jonathan Davies (85 Caps)
13. George North (99 Caps)
14. Louis Rees-Zammit (6 Caps)
15. Liam Williams (68 Caps)
Replacements:
16. Elliot Dee (34 Caps)
17. Rhodri Jones (19 Caps)
18. Leon Brown (14 Caps)
19. Cory Hill (29 Caps)
20. James Botham (4 Caps)
21. Gareth Davies (59 Caps)
22. Callum Sheedy (6 Caps)
23. Uilisi Halaholo (1 Cap)
You can keep in touch with both camps as we head for round two of the Guinness Six Nations for the Wales v England clash on Saturday – we’ve got interviews, videos and social posts covered right here.
