This year’s tournament consists of two pools of three teams before concluding with a finals day on April 24. Wales are in Pool B alongside France and Ireland.
Pool A consists of England, Italy and Scotland.
The Championship will start on April 3 with Wales’ two pool games away to France and at home to Ireland respectively.
Warren Abrahams’ side will travel to the Stade de la Rabine in Vannes to take on France in round one with a kick-off time of 8pm.
They will then meet Ireland at Cardiff Arms Park in round two on April 10 (kick-off 5pm).
Each team will play one home and one away fixture before facing the opposing ranked team from the other pool in a ‘Super Saturday’ finals day.
The Pool A teams – England, Italy and Scotland – will have home games for the finals.
Six Nations chief executive Ben Morel commented: “We are extremely excited to get the Women’s Six Nations underway and with a new window and a new format for fans to engage with.
“Our Super Saturday on April 24 looks set to ensure this year’s Championship has a compelling finale.
“Developing the Women’s Championship is absolutely central to our overall strategy.
“Fans have been thrilled by the Guinness Six Nations over the last two months and now the baton passes to the women’s teams. We expect an equally thrilling sporting spectacle.”
We are extremely excited to get the Women’s Six Nations underway and with a new window and a new format for fans to engage with
France and England will also play a Women’s Six Nations exhibition game as part of the series with the two set to meet at Villeneuve d’Ascq on Friday, April 30.
As well as a new format, the 2021 Women’s Six Nations will also break new ground in broadcasting.
For the first time, all games will be available in one place in the UK, the Republic of Ireland and Italy, with the BBC, RTÉ and Eurosport carrying all nine matches on a mix of terrestrial and digital services.
In the UK, two matches will be shown on terrestrial television. BBC Wales will show Wales against Ireland and the final game involving England will be shown on BBC2 network, meaning a Women’s Six Nations game will be shown on the main BBC network for the first time.
All other games will be on BBC iPlayer.