A late Josh Adams try which was converted by Gareth Anscombe saw Wales clinch a 13-12 win in Bloemfontein to level the test series after their opening defeat in Pretoria seven days earlier. Nienaber has responded by making wholesale changes once again but one constant is giant second-row Eben Etzebeth who will win his 100th cap while hooker Bongi Mbonambi will his 50th.
Half-backs Handre Pollard and Jaden Hendrikse along with prop Trevor Nyakane and flanker Piete-Steph du Toit are the other four players to retain their places in the starting XV. Nienaber named a new-look backline featuring the versatile Damian Willemse at fullback, with Cheslin Kolbe and Makazole Mapimpi back on the wings, while the regular centre pairing of Damian de Allende and Lukhanyo Am will again partner up in the midfield.
Siya Kolisi reclaims the captaincy with du Toit, and Jasper Wiese making up the back-row. The other changes up front see Lood de Jager pair up with Etzebeth in the second row, while Nienaber named a new front row of props Nyakane and Frans Malherbe on either side of Mbonambi.
There were an array of changes among the replacements, which again features a split of six forwards and two backs, with Steven Kitshoff (prop), Franco Mostert, Kwagga Smith, and Elrigh Louw (flanker) featuring alongside scrumhalf Faf de Klerk and fullback Willie le Roux.
Eleven Springboks players in the starting side in Cape Town began the 2019 World Cup final in Japan where South Africa defeated England.
South Africa: Damian Willemse; Cheslin Kolbe, Lukhanyo Am, Damian de Allende, Makazole Mapimpi; Handre Pollard, Jaden Hendrikse; Trevor Nyakane, Bongi Mbonambi, Frans Malherbe, Eben Etzebeth, Lood de Jager, Siya Kolisi (capt), Pieter-Steph du Toit, Jasper Wiese,
Replacements: Malcolm Marx, Steven Kitshoff, Vincent Koch, Franco Mostert, Kwagga Smith, Elrigh Louw, Faf de Klerk, Willie le Roux.