Centre Hannah Jones will captain the side for the visit to Scotland, where scrum half Keira Bevan will win her 50th cap for Wales.
Cunningham saw his team beat Ireland 31-5 in front of a record crowd in the tournament opener at the Arms Park on Saturday. There is one enforced change in the pack due to the knee injury picked up by second row Gwen Crabb and two positional changes.
Georgia Evans moves into the second row to partner Abbie Fleming, with Sioned Harries starting at No8. Bethan Lewis moves across the back row to blindside flanker.
Otherwise, the side sees skipper Jones partner Kerin Lake in the midfield, with Elinor Snowsill at fly-half.
The back three remain the same with Courtney Keight at full-back and Lisa Neumann and Carys Williams Morris on the wings.
Gwenllian Pyrs, Kelsey Jones and Sisilia Tuipulotu are the Wales front row, with openside flanker Alex Callender completing the back row, alongside Harries and Lewis.
Cunningham, said: “This team deserves the opportunity to build on the performance against Ireland for what we know will be a tough challenge away in Scotland.
“Scotland will still be hurting after the manner of our victory at the World Cup in New Zealand.
“While it was one of the best performances we have produced as a team in Cardiff there are plenty of areas to improve on. We have worked on those facets all week.
“The bonus point win showed we can score tries and that is one of the areas we have targeted to improve on in this campaign. To score those tries will give us real confidence in the way we want to play and attack.
“We have been forced into one change due to Gwen Crabb’s injury and the coaches, players and staff are all incredibly disappointed for her after she worked so hard to get back on the field.
“Gwen will get all the support she needs from us and I know she will be back.”
Wales Women’s Senior team to face Scotland in the 2023 TikTok Six Nations
15 Courtney Keight
14 Lisa Neumann
13 Hannah Jones (captain)
12 Kerin Lake
11 Carys Williams-Morris
10 Elinor Snowsill
9 Keira Bevan;
1 Gwenllian Pyrs
2 Kelsey Jones
3 Sisilia Tuipulotu
4 Abbie Fleming
5 Georgia Evans
6 Bethan Lewis
7 Alex Callender
8 Sioned Harries
Replacements
16 Carys Phillips
17 Cara Hope
18 Cerys Hale
19 Natalia John
20 Kate Williams
21 Ffion Lewis
22 Lleucu George
23 Hannah Bluck
