Jenkins has been ruled out due to illness while Williams misses the game because of a knee injury.
Gloucester’s Freddie Thomas now starts in the second row, while Scarlerts’ Blair Murray comes in at fullback.
Cardiff second row Teddy Williams and Gloucester utility back Josh Hathaway join the Wales replacements’ bench.
Wales team v Italy
15. Blair Murray (Scarlets – 4 caps)
14. Tom Rogers (Scarlets – 6 caps)
13. Nick Tompkins (Saracens – 39 caps)
12. Eddie James (Scarlets – 3 caps)
11. Josh Adams (Cardiff Rugby – 60 caps)
10. Ben Thomas (Cardiff Rugby – 8 caps)
9. Tomos Williams (Gloucester Rugby – 60 caps)
1. Gareth Thomas (Ospreys – 36 caps)
2. Evan Lloyd (Cardiff Rugby – 6 caps)
3. Henry Thomas (Scarlets – 5 caps)
4. Will Rowlands (Racing 92 – 37 caps)
5. Freddie Thomas (Gloucester Rugby – 2 caps)
6. James Botham (Cardiff Rugby – 17 caps)
7. Jac Morgan (Ospreys – 19 caps) – captain
8. Taulupe Faletau (Cardiff Rugby – 104 caps)
Replacements
16. Elliot Dee (Dragons – 52 caps)
17. Nicky Smith (Leicester Tigers – 50 caps)
18. Keiron Assiratti (Cardiff Rugby – 11 caps)
19. Teddy Williams (Cardiff Rugby – 2 caps)
20. Aaron Wainwright (Dragons – 53 caps)
21. Rhodri Williams (Dragons – 6 caps)
22. Dan Edwards (Ospreys – 1 cap)
23. Josh Hathaway (Gloucester Rugby – 2 caps)
