The starting line-up is unchanged from the third-round home encounter against Ireland two weeks ago.
Captain Jac Morgan starts at blindside flanker, Tommy Reffell is at openside flanker and Taulupe Faletau completes the back row at No. 8.
In the front row Nicky Smith is selected at loosehead prop, Elliot Dee is at hooker and WillGriff John is tighthead prop for the match.
Will Rowlands and Dafydd Jenkins continue their partnership in the second row.
Tomos Williams is named at scrum-half. Gareth Anscombe is named at fly-half.
Ben Thomas partners Max Llewellyn in the midfield.
Tom Rogers joins Ellis Mee, who made his Wales debut last time out, on the wing, while Blair Murray completes the starting XV at fullback.
There are two changes among the replacements: hooker Dewi Lake is in line to make his first Guinness Six Nations appearance for Wales since 2022. Tighthead prop Keiron Assiratti also returns to the match-day 23.
Gareth Thomas, Teddy Williams and Aaron Wainwright provide the remaining forward cover.
Rhodri Williams, Jarrod Evans and Joe Roberts are the replacement backs for the second match in succession.
Sherratt said: “This week we’ve challenged ourselves to keep improving.
“We want to keep the same intent and bravery as we showed last time out, but making sure that we are building on our game.
“We’re excited for the challenge of playing Scotland in Edinburgh and can’t wait to get out there on Saturday.”
Wales team v Scotland
15. Blair Murray (Scarlets – 6 caps)
14. Tom Rogers (Scarlets – 8 caps)
13. Max Llewellyn (Gloucester Rugby – 6 caps)
12. Ben Thomas (Cardiff Rugby – 10 caps)
11. Ellis Mee (Scarlets – 1 cap)
10. Gareth Anscombe (Gloucester Rugby – 40 caps)
9. Tomos Williams (Gloucester Rugby – 62 caps)
1. Nicky Smith (Leicester Tigers – 52 caps)
2. Elliot Dee (Dragons – 54 caps)
3. WillGriff John (Sale Sharks – 3 caps)
4. Will Rowlands (Racing 92 – 39 caps)
5. Dafydd Jenkins (Exeter Chiefs – 21 caps)
6. Jac Morgan (Ospreys – 21 caps) – captain
7. Tommy Reffell (Leicester Tigers – 25 caps)
8. Taulupe Faletau (Cardiff Rugby – 106 caps)
Replacements
16. Dewi Lake (Ospreys – 18 caps)
17. Gareth Thomas (Ospreys – 38 caps)
18. Keiron Assiratti (Cardiff Rugby – 12 caps)
19. Teddy Williams (Cardiff Rugby – 4 caps)
20. Aaron Wainwright (Dragons – 55 caps)
21. Rhodri Williams (Dragons – 7 caps)
22. Jarrod Evans (Harlequins – 9 caps)
23. Joe Roberts (Scarlets – 3 caps)
