There are two personnel changes to the starting line-up that faced Scotland in Edinburgh last weekend.
In the back row, Aaron Wainwright is named at blindside flanker with captain Jac Morgan moving to openside flanker. Taulupe Faletau is again at No. 8.
Joe Roberts is selected on the left wing to make his first start of the 2025 Championship, with Ellis Mee moving to right wing. Blair Murray completes the back three at fullback.
In the front row Nicky Smith is selected at loosehead prop, Elliot Dee is at hooker and WillGriff John is tighthead prop for the third match in succession.
Will Rowlands and Dafydd Jenkins continue their partnership in the second row.
Tomos Williams is selected at scrum-half with his club teammate Gareth Anscombe selected alongside him at fly-half.
Ben Thomas and Max Llewellyn partner up in the midfield once more to round out the Wales XV.
Nick Tompkins returns to the Wales match day squad and is named alongside Rhodri Williams and Jarrod Evans as the replacement backs.
Dewi Lake, Gareth Thomas, Keiron Assiratti, Teddy Williams and Tommy Reffell provide the forward cover on Saturday.
Sherratt said: “Wales England is always a special occasion and we know it will be an incredible atmosphere at Principality Stadium.
“We’re excited to finish our campaign at home and are looking to put in our best performance on pitch on Saturday.
Wales team v England
15. Blair Murray (Scarlets – 7 caps)
14. Ellis Mee (Scarlets – 2 cap)
13. Max Llewellyn (Gloucester Rugby – 7 caps)
12. Ben Thomas (Cardiff Rugby – 11 caps)
11. Joe Roberts (Scarlets – 4 caps)
10. Gareth Anscombe (Gloucester Rugby – 41 caps)
9. Tomos Williams (Gloucester Rugby – 63 caps)
1. Nicky Smith (Leicester Tigers – 53 caps)
2. Elliot Dee (Dragons – 55 caps)
3. WillGriff John (Sale Sharks – 4 caps)
4. Will Rowlands (Racing 92 – 40 caps)
5. Dafydd Jenkins (Exeter Chiefs – 22 caps)
6. Aaron Wainwright (Dragons – 56 caps)
7. Jac Morgan (Ospreys – 22 caps) – captain
8. Taulupe Faletau (Cardiff Rugby – 107 caps)
Replacements
16. Dewi Lake (Ospreys – 19 caps)
17. Gareth Thomas (Ospreys – 39 caps)
18. Keiron Assiratti (Cardiff Rugby – 13 caps)
19. Teddy Williams (Cardiff Rugby – 5 caps)
20. Tommy Reffell (Leicester Tigers – 26 caps)
21. Rhodri Williams (Dragons – 8 caps)
22. Jarrod Evans (Harlequins – 10 caps)
23. Nick Tompkins (Saracens – 40 caps)
