Scarlets name European side
Stephen Jones returns to flyhalf with Ceiron Thomas moving back to full-back while Regan King moves to outside centre to allow Gavin Evans to return to inside centre, with Matthew Watkins making way.
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There are four changes in the pack with Iestyn Thomas coming in for Phil John at loosehead and Craig Dunlea replaces Deacon Manu on the tighthead.
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In the backrow Gavin Thomas replaces James Bater which forces captain Simon Easterby back to the blindside while in the second row Vernon Cooper comes in for Adam Jones.
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Scarlets (v London Irish): 15 Ceiron Thomas 14 Dafydd James 13 Regan King 12 Gavin Evans 11 Mark Jones 10 Stephen Jones 9 Dwayne Peel; 1 Iestyn Thomas 2 Matthew Rees 3 Craig Dunlea 4  Vernon Cooper 5 Inoke Afeaki 6 Simon Easterby ( capt) 7 Gavin Thomas 8 Alix Popham.
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Replacements: Aled Gravelle, Deacon Manu, Adam Jones, Nathan Thomas, Clive Stuart-Smith, Darren Daniel, Barry Davies