Centre Luke Williams starts in place of Nathan Edwards while No8 Ieuan Jones comes in for Reuben Tucker.
The rest of the side remains unchanged from the side that faced Ireland last week although there are four changes to the bench.
Wilson is looking forward to Wales’ first home game of the tournament and the inaugural international match at Eirias.
“Every week we are together is only going to be beneficial to us as a squad. There was no lack of effort or commitment last weekend and the boys stuck to it right until the end,” he said.
“Scotland will be chasing their first win as well after having a very tough game against England last weekend. We are fully aware they are a very passionate side and we will pay them the greatest respect tonight.
“The boys are really excited about playing our first game at Eirias and hopefully we can make it a venue where teams fear coming to. There’s a proud history up there, the fact all our home games are being staged here is an important signpost for the future of the game in North Wales.”
Wales Under 20s v Scotland
15 Ross Jones
14 Iolo Evans
13 Luke Williams
12 Cory Allen
11 Luke Morgan
10 Sam Davies
9 Jonathan Evans
1 Rob Evans
2 Kirby Myhill (Captain)
3 WillGriff John
4 Matthew Screech
5 Rhodri Hughes
6 Ellis Jenkins
8 Ieuan Jones
7Daniel Thomas
Replacements
16 Darran Harris
17 Thomas Davies
18 Dan Suter
19 Thomas Young
20 Dan Crimmins
21 Joshua Davies
22 Jordan Williams
23 Dominic Franchi
Those travelling to the game are advised to arrive early if without a ticket and leave time for parking. Car parking will be at a premium with Ysgol Bryn Elian utilised as a park and walk car park and the Bay View Shopping Centre hosting a park and ride car park. A minibus will also be collecting supporters from Colwyn Bay train station and returning them after the game free of charge.
Wales v Scotland 10/02/12 KO 19.35
Wales v Italy 09/03/12 KO 19.10
Wales v France 16/03/12 KO 19.35
For further information please call Eirias Leisure Centre directly on 01492 577900. Tickets are available from the centre or can be purchased from Venue Cymru on 01492 872000