Cardiff renew acquaintances with Newbridge, while Llanelli travel to Caerphilly, where they suffered a bad defeat last season by 33-20, while Bridgend, who have lost Jonathan Rimmer to Melrose, face a Cross keys side short of fit back-row forwards.
Aberavon have to decide between prodigious points-scorer Jamie Davies and Widnes Rugby Leaguer Aled James at fly half against Ebbw Vale; Bedwas will test Swansea severely and in-form Carmarthen Quins take on out-of-form Pontypridd.
The best of the Premier games could be at the Gnoll, where Neath entertain a Pontypool side, who will be hard pushed to repeat last Saturday’s wonderful display against Bridgend. Former Wales Youth cap Ben Jeffries, in particular, is a player to watch.