The troubled Division Two East programme has a powerful match at Ystrad Rhondda, where unbeaten Fleur de Lys are the visitors and in Two West there are two fascinating matches as leaders Dunvant visit Cwmllynfell and Corus entertain Felinfoel.
Potypool United, after a splendid win at Newport HSOB, take on the powerful Newport Saracens in Three East and Pill Harriers will face a hard match against Llanishen. In Three West, the top clash is at Pontyberem, where both they and Kidwelly are unbeaten and Haverfordwest with seven straight wins will face an in-form Hendy.
It is a top-of-the-table clash in Three South East as Tylorstown meet Gilfach Goch and another excellent match will be between Mountain Ash and Rhydyfelin, while Three South West will include Maesteg Quins versus Glynneath and Bryncoch away to Ystradgynlais.
Division Four East leaders Bargoed defend their unbeaten record at home to Pontllanfraith and Blain make the trip to the Diamond Ground to play Cardiff HSOB, while in Division Four West unbeaten Loughor travel to Milford Haven.
The Pontycymmer-Pontyclun and Fairwater-Abercwmboi matches head Division Four South East and in Four South West Taibach should stay in front as they take the journey to play bottom club Maesteg Celtic.
In the North, bottom club Bala have to face powerful Nant Conwy, while leaders Ruthin go to Wrexham in Division Four and in Division Five, the leaders Denbigh are at Bethesda with unbeaten Colwyn Bay traveling to Welshpool.
Machen against Bettws tops the Division Five East programme and Trinant face a tough task at Nantyglo. In the West Crymych have a chance to go top if they in well at Penygroes as Cefneithin’s match at Pontyates is off.
The local derby between Llandaff and Llandaff North heads Five South-East, where Llantwit Major face a tight match with Cilfynydd and Five West includes Resolven at home to Cwmtwrch and an interesting match between Aberavon Green Stars and Pontardawe.