The Welsh side sit second in the league table after last weekend’s impressive 29-27 win on the road against the same opponents in the Scottish capital.
Welsh international flanker Bryonie King leads a Gwalia Lightning side which sees eight changes with two positional to face a Scottish side fourth in the league.
Welsh internationals Gwennan Hopkins returns at Number 8 with Sian Jones back at scrum half.
Prop Cana Williams is selected at prop, alongside Welsh international Maisie Davies and Molly Wakely in the front row.
Lily Terry moves to second row to partner Alaw Pyrs in the Lightning engine room.
Rhodd Parry is selected as full-back, with Courtney Greenway moving to one wing with Caitlin Lewis on the other wing.
Kelsie Webster and Anwen Owen are a new and exciting centre partnership for Lightning, with experienced centre Kerin Lake ruled out due to a leg injury.
Catrina Nicholas-McLaughlin, Gwalia Lightning head coach, said: “We are well aware that Edinburgh will be hurting after last weekend and we will have to be aware of the threats they posed in our last game.
“We showed character and resilience in defence and the ability to play attacking rugby and that is very much part of the identity we want to establish as Gwalia Lightning.
“We deserve to be second in the league but it does mean teams will raise their game against us and we have to deal with that. Ourselves and Edinburgh want to attack and play, and we expect it to be another close and exciting contest.”
Gwalia Lighting (v Edinburgh)
Rhodd Parry, Courtney Greenway, Kelsie Webster, Anwen Owen, Caitlin Lewis, Carys Hughes, Sian Jones; Maisie Davies, Molly Wakely, Cana Williams, Lily Terry, Alaw Pyrs, Bryonie King (captain), Catrin Stewart, Gwennan Hopkins.
Replacements: Mollie Mae Crabb, Dali Hopkins, Danyelle Dinapoli, Lottie Buffery-Latham, Katie Bevans, Freya Bell, Carys Williams-Morris, Jenny Hesketh
