The experienced Irish side proved to strong for a young and inexperienced Welsh side and underlined why the two sides across the Irish sea have dominated the League.
The Thunder were without inspirational captain, Natalia John, who was ruled with injury with Katie Carr named as skipper for the visit of the Irish side.
Lock Catrin Jones crossed for a try on her Brython Thunder debut in the second half. But Brython Thunder came into this contest with a first win in the Celtic Challenge at the same venue in the previous round.
The Irish side came to Wales with a side full of Irish internationals and second in the league table before kick-off.
Clovers opened the scoring through flanker Faith Oviawe who raced in from the half way line. Fly half Caitriona Finn converted the conversion to make it 7-0.
The Irish side demonstrated their forward power when they scored their second try by lock Jane Neill to make it 12-0 after five minutes.

Catrin Jones scores for Brython Thunder
Prop Grainne Burke them crossed for a third try with Brython Tunder pack struggling with the power of the Irish side’s engine room. Finn added the extras to make it 19-0 after 10 minutes.
Wing and captain Amee Leigh Costigan crossed for the fourth and bonus-point try and hooker Emily Gavin scored Clovers fifth try to make it 29-0 midway through the first half.
Clovers saw scrum half Emily Lane, flanker Brianna Heylmann, centre Anna McGann and a penalty try to keep the scoreboard ticking over.
Thunder scrum half Seren Singleton was shown a yellow card and was held up over the Clovers  line before the Irish side went in 51-0 ahead at half-time.
After the break, prop Saoirse Crowe, hooker Emily Gavin, scrum half Grainne Moran, skipper Costigan, Beth Buttimer, McGann and Oviawe all crossed for tries for the visitors.
But Thunder crossed for a try by second row Jones after a period of pressure and converted by fly half Hanna Marshall midway through the second half.
ENDS