Earlier in the season, the Dragons beat Perpignan with a comfortable 10-point lead at Rodney Parade. They’ll be aiming for a double win tomorrow at Stade Aimé Giral.
The Dragons go into the match missing a number of front line players. Fly-half Jason Tovey (leg), wing Tonderai Chavhanga (ribs), centre Ashley Smith (hamstring) and hooker Lloyd Burns (illness) all miss out through injury.
Flanker Gavin Thomas (knee) is also ruled out of the trip to the Stade Aime Giral, but Adam Hughes is fit.
The French side go into the final two rounds top of the group but have struggled in the domestic Top 14 this season, winning five of 15 league games.
Newport Gwent Dragons Martyn Thomas, Will Harries, Adam Hughes, Lewis Robling, Aled Brew, Matthew Jones, Wayne Evans, Nathan Williams, Steve Jones, Nathan Buck, Adam Jones, Rob Sidoli, Danny Lydiate (c), Lewis Evans, Toby Faletau
Replacements: Rhys Buckley, Phil Price, Dan Way, Hugh Gustafson, Tom Brown, Jonathan Evans, Andy Tuilagi, Tom Riley