The Welsh region are unbeaten at home in the competition and face the pool’s bottom side Rovigo who have conceded more than 65 points in each of their previous away games.
However assistant coach Paul John insists Blues will remain vigilant as they target a place in the last eight.
John said: “The message all week to the players is to guard against any complacency. We have been watching and studying Rovigo just as did for facing Leinster the previous week in the Pro12.
“We didn’t have an easy game out in Italy so we cannot disrespect them as opponents. It is a European tie and we have to win it if we have any aspirations of going further in the competition and we want to be in the quarter-finals.
“It’s all about mental discipline and if we get things right over the next two weeks we will have something very exciting to look forward to later in the season and the chance to win silverware.”
Cardiff will be without injured skipper Sam Warburton and suspended former All Black Jarrad Hoeata as well as new signings, Argentina internationals Joaquin Tuculet and Lucas Amorosino, who are yet to be registered.
Italians Rovigo have not played in Wales in 13 years and while they may be bottom of Pool 1, they possess individuals who have caused opponents plenty of problems.
Lock Jean-Francis Montauriol has proved the most dominant line-outs player in the entire tournament while wing Billy Ngawini has beaten more defenders than any other player.