The Tongan-born No.8 is a cousin of England brothers Mako and Billy Vunipola, and shared a home with the duo while their fathers played for Ebbw Vale.
Mako has been selected on the bench as England seek a first Grand Slam in a decade and Faletau reckons the giant prop will have a big impact.
“If he comes off the bench and I’m still on the pitch it will be a great occasion for both of us and our families,” said Faletau.
“Mako’s been great coming off the bench for England he did brilliantly on his first start against Italy. It’s been great to see him doing so well and I’m sure he will be the same tomorrow.
“It’s a shame they’re not playing for Wales but they came through the English system. I’m really pleased they’re playing international rugby and want them to do well.”
Faletau admits the Vunipolas used to get the better of him in on the Gwent playing fields as a child but he reckons Wales will roar at the Millennium Stadium.
“Growing up they were bigger than me and it was them smashing me with tackles on the field Mako definitely used to get the better of me when we were chucking a ball around,” added Faletau.
“You never think there would be a situation where you’d be up against each other in an international, it’s all just fun and games at the time.
“But these big occasions are why you play the game and they don’t come much bigger than a title decide
“After Ireland the title seemed a long way off but the boys have done brilliantly to get back in contention.
“It’s been great to turn it around after eight Test defeats in a row and that is credit to the boys for the hard work that they have done. It would be up there with Grand Slam last year if we could retain the title.”
You can follow every minute of the action between Wales and England at www.wru.co.uk/live just prior to kick-off.
